The start of the NFL season, or for that matter any major sporting event, is also usually a good time to create an office pool with your colleagues.
Whether you bet money or not you can still have good fun guessing the results of games. NFL Office Pool is probably the most advanced in its genre.
Not only can you create pools for all major football leagues (NFL, NFL Europe, CFL. . . ) but also get constantly updated statistics, whether on your friends' picks, official game results and other information.
You can make your picks all in one go, choosing for instance all underdogs or all home teams. We also felt that NFL Office Pool really let you work around your pool, letting you print it out, play over Internet or make safe backups.
The interface itself may not be the most attractive (mostly due to the odd layout of the buttons), but the program is simple enough that it should only take you seconds to create your office pool.